Liverpool take on their rivals Everton in the derby trying to extend their winning streak.
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West Ham play Hornets at home trying to continue their battle for the eurocups zone.
In-form Las-Palmas travel to Betis with hopes to gain some points.
Titleholders PSG travel to Lorient for French cup semifinal clash.
Impressive Celta travel to Catalonia for the head-to-head with Espanyol.
The Old Lady are on the way to winning fifth title in the row.
Classic six-pointed between two teams who involved in relegation battle.
Champions League semifinalist are hoping now to close on Barcelona in Primera.
Europa League semifinalist Sevilla try to gain another home victory.
Athletic try to bounce back after bitter loss to Sevilla on penalties.
Europa League semifinalists travel to inconsistent Rayo Vallecano
Valencia travel to Camp Nou with hopes to use Barcelona’s setback and show better performance after Copa del Rey devastating loss.
Clash of two big clubs who sit on opposite sides of the standings.
Roberto Martinez’s men are seeking for a victory to end their 4-match run without a win.
Arsenal are looking for a victory to secure the third position and challenge neighbors Tottenham.
Impressive Mainz are seeking for three points on their way to qualifying for next season eurocups.
The hosts will be looking for the second win in a row under new manager
Milan travel to Genoa with their new managers and hopes to prove the team can do better that sixth place in the Serie A.
The Champions League quarterfinalists Wolfsburg travel to Bremen for the clash with Werder.
Ronaldo and Co visit Getafe few days after impressive victory that took them to the Champions League semifinals.